DispersinB(R) Effective Against Superbug MRSA
Highlights:
- DispersinB works synergistically with well-known silver based commercial wound dressing to demonstrate an almost 6-fold reduction in MRSA infection
- Silver wound dressing alone had a negligible effect on the MRSA biofilm infection
- Chronic wound mouse study was conducted independently at Texas Tech University Health Sciences Center
WINNIPEG, MANITOBA -- (MARKET WIRE) -- 07/26/11 -- Kane Biotech Inc. (TSX VENTURE: KNE), a biotechnology company engaged in the development and commercialization of products that prevent and remove microbial biofilms is pleased to announce the results of an in vivo efficacy study conducted by Texas Tech University Health Sciences Center in Lubbock, Texas demonstrated DispersinB wound spray is effective against a biofilm-embedded Methicillin-Resistant Staphylococcus aureus (MRSA) strain infection.
Dr. Kendra Rumbaugh at Texas Tech University Health Sciences Center tested DispersinB wound spray in combination with a well known commercial silver wound dressing and the wound dressing alone in a chronic wound mouse model of MRSA infection. The combination of DispersinB and the silver dressing performed much better resulting in almost 6-fold reduction in infection (81% reduction) than the silver dressing alone (14% reduction). This indicates that there is synergy between the two compounds due to DispersinB enhancing the antimicrobial activity of silver against MRSA by disrupting the biofilm.
"While the silver wound dressing alone had a negligible effect on the MRSA biofilm infection, the DispersinB-silver combination significantly reduced the MRSA biofilm infection (P less than 0.05)", stated Dr. Kendra Rumbaugh, Assistant Professor, Department of Surgery, Texas Tech University Health Sciences Center, Lubbock. "Thus, the results of this study suggest DispersinB in combination with silver makes biofilm-embedded MRSA more susceptible to killing by silver in the dressing."
"Since silver alone showed minimal efficacy against MRSA, it is a testament to the difficult challenge that the healthcare industry faces in trying to control this superbug associated with chronic infections, including wound infections. DispersinB could provide a valuable tool to help combat MRSA", stated Dr. Sri Madhyastha, Vice President of Research and Chief Scientific Officer of Kane Biotech.
"DispersinB is compatible and synergistic with a number of antimicrobial/antibiotic wound care products, which could prove very useful in managing the chronic non-healing wounds involving biofilm infections in a number of clinical settings." added Dr. Madhyastha.
About Dr. Kendra P. Rumbaugh
Dr. Kendra P. Rumbaugh is an Assistant Professor in the Department of Surgery at the Texas Tech University Health Sciences Center, Lubbock, Texas. Dr. Rumbaugh has over 30 research publications in peer-reviewed scientific journals. Recently, she has published an article entitled "Fatal attraction: Bacterial bait lures worms to their death" in the prestigious journal, "Proceedings of National Academy of Sciences (PNAS), USA." Dr. Rumbaugh has also edited a book entitled "Quorum Sensing: Methods and Protocols", published by Springer, New York. Her major current research projects include: (i) Interkingdom Signaling between P. aeruginosa Quorum Sensing Molecules and Host Cells; and (ii) P. aeruginosa Pathogenesis and Biofilm Formation in Wounds. Dr. Rumbaugh's research is supported by the American Diabetes Association.
About Texas Tech University Health Sciences Center
Beginning in 1969 as Texas Tech University School of Medicine, today Texas Tech University Health Sciences Center is a six-school university located in Abilene, Amarillo, Dallas/Fort Worth, El Paso, Highland Lakes, Lubbock, Midland and Odessa in Texas., The Texas Tech University Health Sciences Center is dedicated to education, patient care and research and has made an impact on the health of West Texas and beyond for almost 40 years. To date, they have trained more than 10,000 health care professionals, and met the health care needs of more than 2.5 million people who live throughout a vast 108-county are stretching from the Texas Panhandle south to the Permian Basin and west into Eastern New Mexico. They have established themselves as a leader in education and patient care and are building a top-ranked research environment with significant studies under way in areas such as aging, cancer, reproduction, genetic diseases and rural health.
About Kane Biotech Inc.
Kane Biotech is a biotechnology company engaged in the development and commercialization of products to prevent and remove biofilms. Biofilms are a major cause of a number of serious medical problems including chronic infections and medical device related infections. They develop on surfaces such as catheters, prosthetic implants, teeth, lungs and the urogenital tract. Biofilms are pervasive, costly to deal with and are involved in approximately 80% of all human bacterial infections. The healing of chronic wounds alone costs the United States health care system $20 Billion per year.
Kane Biotech uses patent protected technologies based on molecular mechanisms of biofilm formation/dispersal and methods for finding compounds that inhibit or disrupt biofilms. The Company has evidence that these technologies have potential to significantly improve the ability to prevent and/or destroy biofilms in several medical and industrial applications.
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Contacts: Kane Biotech Inc. Kam Thindal 604-566-9236 office or 604-488-9875 mobile kam@puread.ca
Source: Kane Biotech Inc.
Released July 26, 2011